2015-2019

201 Stereoselective synthesis of alicyclic ketones: a hydrogen borrowing approach

Roly J. Armstrong, Wasim M. Akhtar, James R. Frost, Kirsten E. Christensen, Neil G. Stevenson, Timothy J. Donohoe

Tetrahedron, 2019, 75, 130680. Steve Davies honor issue, 1-9.

DOI: 10.1016/j.tet.2019.130680

200 Transition metal free reductive hydroxymethylation of isoquinolines

Benjamin M. Reeves, Hamish B. Hepburn, Alex Grozavu, Peter J. Lindsay-Scott, Timothy J. Donohoe

Angewandte Chemie Int. Ed., 2019, 58, 15697-15701.

DOI: 10.1002/anie.201908857

199 1-(4-Methyl-2,6,7-trioxabicyclo[2.2.2]oct-1-yl)-ethane

Christopher Hall and Timothy J. Donohoe

Encyclopedia of Reagents for Organic Synthesis, 2019, ISBN 9780470842898

198 Photochemical alkene isomerisation for the synthesis of polysubstituted furans and pyrroles under neutral conditions

Johannes C. L. Walker, Simon Werrel and Timothy J. Donohoe

Chemistry: A European Journal, 2019, 5,13114 –13118.

DOI: 10.1002/chem.201903590

197 Hypervalent iodine initiated intramolecular alkene dimerization: a stereodivergent entry to cyclobutanes

Yuxiang Zhu, Ignacio Colomer and Timothy J. Donohoe

Chemical Communications, 2019, 55, 10316-10319.

DOI: 10.1039/c9cc04383g

196 Catalytic Asymmetric Synthesis of Cyclohexanes by Hydrogen Borrowing Annulations

Roly J. Armstrong, Wasim M. Akhtar, Tom A. Young, Fernanda Duarte and Timothy J. Donohoe

Angewandte Chemie Int. Ed., 2019, 58, 12558-12562.

DOI: 10.1002/anie.201907514

195 Rhodium-catalysed vinyl 1,4-conjugate addition coupled with Sharpless asymmetric dihydroxylation in the synthesis of the CDE ring fragment of pectenotoxin 4

Melodie Richardson, Darren Poole, Christopher Tame, Timothy J. Donohoe

Chem. Sci., 2019, 10, 6336-6340.

DOI: 10.1039/C9SC01761E

194 HFIP solvent enables alcohols to act as alkylating agents in stereoselective heterocyclisation.

Yuxiang Zhu, Ignacio Colomer, Timothy J. Donohoe

J. Am. Chem. Soc., 2019, 141, 6489-6493.

DOI: https://doi.org/10.1021/jacs.9b02198

193 Synthesis of Lamellarin Alkaloids Using Orthoester-Masked α-Keto Acids

Harry J. Shirley, Maria Koyioni, Filip Muncan, Timothy J. Donohoe

Chem. Sci., 2019, 10, 4334 - 4338.

DOI: 10.1039/C8SC05678A

192 The reductive C3 functionalization of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation

Alexandru Grozavu, Hamish B. Hepburn, Philip J. Smith, Harish K. Potukuchi, Peter J. Lindsay-Scott, Timothy J. Donohoe

Nature Chemistry, 2019, 11, 242-247.

DOI: 10.1038/s41557-018-0178-5

191 Stereoselective synthesis of cyclohexanes via an iridium catalysed (5+1) annulation strategy

Wasim M. Akhtar, Roly J. Armstrong, James R. Frost, N. G. Stevenson, Timothy J. Donohoe

J. Am. Chem. Soc., 2018, 140, 11916-11920.

DOI: 10.1021/jacs.8b07776

190 OBO-protected pyruvates as reagents for the synthesis of functionalized heteroaromatic compounds

C. Henrique Alves Estavez, Maria Koyioni, Kirsten E. Christensen, Peter D. Smith, Timothy J. Donohoe

Organic Letters, 2018, 20, 4048-4051.

DOI: 10.1021/acs.orglett.8b01614

189 Asymmetric Total Synthesis of (-)-(3R)-Inthomycin C

Sandra Balcells, Maxwell B. Haughey, Johannes C. L. Walker, Laia Josa-Cullere, Christopher Towers, Timothy J. Donohoe

Organic Letters, 2018, 20, 3583-3586.

DOI: 10.1021/acs.orglett.8b01370

188 The efficacy of the quercetin analogue LY294002 in immortalized cancer cell lines is related to the oxygenic and metabolic status of cells

Xinyue Huang, Michelle Potter, Ben Pilgrim, Ruchuta Ardkhean, Mikail Kabeshov, Timothy Claridge, Matthew Wiseman, Karl Jonathan Morten, Timothy Donohoe, Helen Elizabeth Townley

Int. J. Cancer Ther. Oncol., 2017, 5, 51X.

DOI: 10.14319/ijcto.51.14

187 Cobalt versus osmium: control of both trans and cis selectivity in construction of the EFG rings of pectenotoxin 4.

Ahria Roushanbakhti, Yifan Liu, Paul C. M. Winship, Michael J. Tucker, Wasim M. Akhtar, Daryl S. Walter, Gail Wrigley and Timothy J. Donohoe

Angewandte Chemie Int. Ed., 2017, 56, 14883-14887.

DOI: 10.1002/anie.201708278

186 Hexafluoroisopropanol as a highly versatile solvent.

Ignacio Colomer, Anna E. R. Chamberlain, Maxwell B. Haughey and Timothy J. Donohoe

Nature Reviews Chemistry, 2017, 1, 0088.

DOI: 10.1038/s41570-017-0088

185 Pyruvate Enolate Arylation and Alkylation: OBO Ester Protected Pyruvates as Useful Reagents in Organic Synthesis

Carlos Henrique Esteves, Christopher J. J. Hall, Peter Smith and Timothy J. Donohoe

Organic Letters, 2017, 19, 5248-5251.

DOI: 10.1021/acs.orglett.7b02524

184 Catalytic enolate arylation with 3-bromoindoles allows the formation of beta-carbolines.

C. Henrique Estavez Alves, Peter D. Smith, and Timothy J. Donohoe

J. Org. Chem. 2017, 82, 4435-4443.

DOI: 10.1021/acs.joc.7b00299

183 Hydrogen Borrowing Catalysis with Secondary Alcohols: A New Route for the Generation of β-Branched Carbonyl Compounds.

Wasim M. Akhtar, Choon Boon Cheong, James R. Frost, Kirsten E. Christensen, Neil G. Stevenson, and Timothy J. Donohoe

J. Am. Chem. Soc., 2017, 139, 2577-2580.

DOI: 10.1021/jacs.6b12840

182 Diastereoselective synthesis of the 5-hydroxy-pyrrolidinone amino acid of the microsclerodermins and model studies for an end-game strategy for microsclerodermin B

Christian Winter, Robert D. C. Pullin and Timothy J. Donohoe

Tetrahedron Letters, 2017, 58, 602-605.

DOI: 10.1016/j.tetlet.2016.12.045

181 Orthogonally protected 1,2 diols from electron-rich alkenes using metal free olefin syn dihydroxylation

Ignacio Colomer, Rosimeire Coura Barcelos, Kirsten E. Christensen, Timothy J. Donohoe

Organic Letters, 2016, 18, 5880-5883.

DOI: 10.1021/acs.orglett.6b02959

180 Dehydromicrosclerodermin B and microsclerodermin J: total synthesis and structural revision

Ekaterina Y. Melikhova, Robert D. C. Pullin, Christian Winter, Timothy J. Donohoe

Angewandte Chemie Int. Ed., 2016, 55, 9753-9757.

DOI: 10.1002/ange.201604764

179 Hydrogen bonding to hexafluoroisopropanol controls the oxidative strength of hypervalent iodine reagents

Ignacio Colomer, Christopher Batchelor-McAuley, Barbara Odell, Timothy J. Donohoe, Richard Compton

J. Am. Chem. Soc. 2016,138, 8855-886.

DOI: 10.1021/jacs.6b04057

178 Iridium-Catalyzed C4-Alkylation of 2,6-Di-tert-butylphenol using Hydrogen Borrowing Catalysis

James R. Frost, Choon Boon Cheong, Timothy J. Donohoe

Synthesis, 2016, 49, 910-916.

DOI: 10.1055/s-0035-1561439

177 Synthesis of aromatic heterocycles using ring-closing metathesis

Harish K. Potukuchi, Ignacio Colomer, Timothy J. Donohoe

Advances in Heterocyclic Chemistry: Alan Katritzky Tribute volume, Chapter 15, 2016, Elsevier, 43-65.

DOI: 10.1016/bs.aihch.2016.04.006

176 Catalytic hypervalent iodine promoters allow styrene dimerisation and the formation of tri- and tetrasubstituted cyclobutanes

Ignacio Colomer, Rosimeire Coura Barcelos and Timothy J. Donohoe

Angewandte Chemie Int. Ed., 2016, 55, 4748-4752.

DOI: 10.1002/anie.201511683

175 Palladium-catalysed enolate arylation as a key C-C bond forming reaction for the synthesis of isoquinolines

Ben S. Pilgrim, Alice E. Gatland, Carlos H. A. Estaves, Charlie T. McTernan, Geraint R. Jones, Matthew R. Tatton, Panayiotis A. Procopiou, Timothy J. Donohoe

Organic and Biomolecular Chemistry, 2016, 14, 1065-1090. Designated as a HOT article.

DOI: 10.1039/C5OB02320C

174 Strategic application and transformation of ortho-di-substituted phenyl and cyclopropyl ketones to expand the scope of hydrogen borrowing catalysis

James R. Frost, Choon Boon Cheong, Wasim M. Akhtar, Dimitri F. J. Caputo, Neil G. Stevenson and Timothy J. Donohoe

J. Am. Chem. Soc. 2016, 137, 15664-15667.

DOI: 10.1021/jacs.5b11196

173 Application of catalytic Z-selective olefin metathesis in natural product synthesis

Simon Werrel, Johannes C. L. Walker and Timothy J. Donohoe

Tetrahedron Letters, 2015, 56, 5261-5268.

DOI: 10.1016/j.tetlet.2015.07.008

172 Aziridine electrophiles in the functionalisation of peptide chains with amine nucleophiles

Anatol P. Spork and Timothy J. Donohoe

Organic and Biomolecular Chemistry, 2015, 13, 8545-8549.

DOI: 10.1039/C5OB00856E

171 Modular Synthesis of Highly Substituted Pyridines via Enolate α-Alkenylation

Leo A. Hardegger, Jacqueline Habegger and Timothy J. Donohoe

Organic Letters, 2015, 17, 3222-3225.

DOI: 10.1021/acs.orglett.5b01312

170 Palladium-catalyzed alpha-arylation of carbonyls in the de novo synthesis of aromatic heterocycles

Harish K. Potukuchi, Anatol P. Spork and Timothy J. Donohoe

Organic and Biomolecular Chemistry, 2015, 13, 4367-4373.

DOI: 10.1039/C5OB00055F

169 Hydrogen borrowing and interrupted hydrogen borrowing reactions of ketones and methanol, catalysed by iridium

Di Shen, Darren L. Poole, Camilla C. Shotton, Anne F. Kornahrens, Mark P. Healy and Timothy J. Donohoe

Angewandte Chemie Int. Ed., 2015, 54, 1642-1645.

DOI: 10.1002/anie.201410391